Small Molecules Inducing Autophagic Degradation of Expanded Polyglutamine Protein through Interaction with Both Mutant ATXN3 and LC3

Te-Hsien Lin, Wan-Ling Chen, Shao-Fan Hsu, I-Cheng Chen, Chih-Hsin Lin, Kuo-Hsuan Chang, Yih-Ru Wu, Yi-Ru Chen, Ching-Fa Yao, Wenwei Lin, Guey-Jen Lee-Chen, Chiung-Mei Chen

International Journal of Molecular Sciences 25 (19), 10707

Investigating the therapeutic effects of novel compounds targeting inflammatory IL-1β and IL-6 signaling pathways in spinocerebellar ataxia type 3

I-Cheng Chen, Wan-Ling Chen, Kuo-Hsuan Chang, Jun-Wei Lee, Te-Hsien Lin, Wenwei Lin, Chiung-Mei Chen, Guey-Jen Lee-Chen

European Journal of Pharmacology 967, 176370

Effects of chitosan on chondrocytes derived from human nasal septal cartilage

Yu-Hsun Chiu, I-Cheng Chen, Tzu-Han Lin, Tai-Horng Young, Hsu-Wei Fang

in vivo 37 (5), 2001-2005

Investigation and characterization of factors affecting rheological properties of poloxamer-based thermo-sensitive hydrogel

I-Cheng Chen, Chen-Ying Su, Pei-Yu Chen, The Chien Hoang, Yi-Syue Tsou, Hsu-Wei Fang

Polymers 14 (24), 5353

Preparation and characterization of extracellular matrix hydrogels derived from acellular cartilage tissue

Tsong-Hann Yu, Tsu-Te Yeh, Chen-Ying Su, Ni-Yin Yu, I-Cheng Chen, Hsu-Wei Fang

Journal of Functional Biomaterials 13 (4), 279

Development of injectable calcium sulfate and self-setting calcium phosphate composite bone graft materials for minimally invasive surgery

Yu-Hsun Chiu, I-Cheng Chen, Chen-Ying Su, Hsin-Hua Tsai, Tai-Horng Young, Hsu-Wei Fang

International Journal of Molecular Sciences 23 (14), 7590

Evaluating pull-out strength of barbed suture In vitro by using porcine tissue and polydimethylsiloxane (PDMS)

Wei Hong, I-Cheng Chen, Chen-Ying Su, Cherng-Kang Perng, Hsu Ma, Hsu-Wei Fang

Polymers 14 (11), 2170

Preparation and characterization of moldable demineralized bone matrix/calcium sulfate composite bone graft materials

I-Cheng Chen, Chen-Ying Su, Chun-Cheih Lai, Yi-Syue Tsou, Yudong Zheng, Hsu-Wei Fang

Journal of Functional Biomaterials 12 (4), 56

Preventative treatment of red light-emitting diode protected osteoarthritis-like chondrocytes from oxidative stress-induced inflammation and promoted matrix gene expression

I-Cheng Chen, Chen-Ying Su, Chi-Hau Fang, Hsu-Wei Fang

Journal of the Taiwan Institute of Chemical Engineers 127, 23-31

Influence of antibiotic-loaded acrylic bone cement composition on drug release behavior and mechanism

I-Cheng Chen, Chen-Ying Su, Wei-Han Nien, Tzu-Tien Huang, Chang-Hung Huang, Yung-Chang Lu, Yu-Jen Chen, Gwo-Che Huang, Hsu-Wei Fang

Polymers 13 (14), 2240

Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models

Chiung-Mei Chen, Wan-Ling Chen, Chen-Ting Hung, Te-Hsien Lin, Ming-Chung Lee, I-Cheng Chen, Chih-Hsin Lin, Chih-Ying Chao, Yih-Ru Wu, Kuo-Hsuan Chang, Hsiu Mei Hsieh-Li, Guey-Jen Lee-Chen

Aging (Albany NY) 11 (3), 986

Targeting ubiquitin proteasome pathway with traditional Chinese medicine for treatment of spinocerebellar ataxia type 3

I-Cheng Chen, Chia-Ning Chang, Wan-Ling Chen, Te-Hsien Lin, Chih-Ying Chao, Chih-Hsin Lin, Hsuan-Yuan Lin, Mei-Ling Cheng, Mu-Chun Chiang, Jung-Yaw Lin, Yih-Ru Wu, Guey-Jen Lee-Chen, Chiung-Mei Chen

The American Journal of Chinese Medicine 47 (01), 63-95

Pueraria lobata and Daidzein Reduce Cytotoxicity by Enhancing Ubiquitin‐Proteasome System Function in SCA3‐iPSC‐Derived Neurons

I-Cheng Chen, Kuo-Hsuan Chang, Yi-Jing Chen, Yi-Chun Chen, Guey-Jen Lee-Chen, Chiung-Mei Chen

Oxidative medicine and cellular longevity 2019 (1), 8130481

Formulated Chinese medicine Shaoyao Gancao Tang reduces tau aggregation and exerts neuroprotection through anti‐oxidation and anti‐inflammation

I-Cheng Chen, Te-Hsien Lin, Yu-Hsuan Hsieh, Chih-Ying Chao, Yih-Ru Wu, Kuo-Hsuan Chang, Ming-Chung Lee, Guey-Jen Lee-Chen, Chiung-Mei Chen

Oxidative medicine and cellular longevity 2018 (1), 9595741

Medicinal herbs Oenanthe javanica (Blume) DC., Casuarina equisetifolia L. and Sorghum bicolor (L.) Moench protect human cells from MPP+ damage via inducing FBXO7 expression

Chiung-Mei Chen, I-Cheng Chen, Ying-Lin Chen, Te-Hsien Lin, Wan-Ling Chen, Chih-Ying Chao, Yih-Ru Wu, Yeah-Ting Lu, Cheng-Yu Lee, Hong-Chi Chien, Ting-Shou Chen, Guey-Jen Lee-Chen, Chi-Mei Lee

Phytomedicine 23 (12), 1422-1433

Novel lactulose and melibiose targeting autophagy to reduce polyQ aggregation in cell models of spinocerebellar ataxia 3

Chih-Hsin Lin; Yih-Ru Wu; Jinn-Moon Yang; Wan-Ling Chen; Chih-Ying Chao; I-Cheng Chen; Te-Hsien Lin; Yi-Ci Wu; Kai-Cheng Hsu; Chiung-Mei Chen; Guan-Chiun Lee; Hsiu-Mei Hsie-Li; Chi-Mei Lee; Guey-Jen Lee-Chen

CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders) 15 (3), 351-359

Impairment of proteasome and anti-oxidative pathways in the induced pluripotent stem cell model for sporadic Parkinson’s disease

Kuo-Hsuan Chang, Guey-Jen Lee-Chen, Yih-Ru Wu, Yi-Jing Chen, Jia-Li Lin, Meng Li, I-Cheng Chen, Yen-Shi Lo, Hsiu-Chuan Wu, Chiung-Mei Chen

Parkinsonism & related disorders 24, 81-88

The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer’s disease

Kuo-Hsuan Chang, I-Cheng Chen, Hsuan-Yuan Lin, Hsuan-Chiang Chen, Chih-Hsin Lin, Te-Hsien Lin, Yu-Ting Weng, Chih-Ying Chao, Yih-Ru Wu, Jung-Yaw Lin, Guey-Jen Lee-Chen, Chiung-Mei Chen

Drug Design, Development and Therapy, 885-896

FBXO7 Y52C Polymorphism as a Potential Protective Factor in Parkinson’s Disease

Chiung-Mei Chen, I-Cheng Chen, Yi-Cheng Huang, Hsueh-Fen Juan, Ying-Lin Chen, Yi-Chun Chen, Chih-Hsin Lin, Li-Ching Lee, Chi-Mei Lee, Guey-Jen Lee-Chen, Yun-Ju Lai, Yih-Ru Wu

PLoS One 9 (7), e101392

Aqueous extract of Glycyrrhiza inflata inhibits aggregation by upregulating PPARGC1A and NFE2L2–ARE pathways in cell models of spinocerebellar ataxia 3

Chiung-Mei Chen, Yu-Ting Weng, Wan-Ling Chen, Te-Hsien Lin, Chih-Ying Chao, Chih-Hsin Lin, I-Cheng Chen, Li-Ching Lee, Hsuan-Yuan Lin, Yih-Ru Wu, Yi-Chun Chen, Kuo-Hsuan Chang, Hsiang-Yu Tang, Mei-Ling Cheng, Guey-Jen Lee-Chen, Jung-Yaw Lin

Free Radical Biology and Medicine 71, 339-350

HTRA2 variations in Taiwanese Parkinson’s disease

Chiung-Mei Chen, Chun-Hsien Wu, Chin-Hsia Hsieh, Chih-Hsin Lin, I-Cheng Chen, Yi-Chun Chen, Li-Ching Lee, Chi-Mei Lee, Yung-Che Tseng, Guey-Jen Lee-Chen, Yih-Ru Wu

Journal of Neural Transmission 121, 491-498

Internal Ribosome Entry Segment Activity of ATXN8 Opposite Strand RNA

I-Cheng Chen, Hsuan-Yuan Lin, Ya-Chin Hsiao, Chiung-Mei Chen, Yih-Ru Wu, Hsin-Chieh Shiau, Yu-Fang Shen, Kuo-Shiu Huang, Ming-Tsan Su, Hsiu-Mei Hsieh-Li, Guey-Jen Lee-Chen

PLoS One 8 (9), e73885

FBXO7 variations in Taiwanese Parkinson’s disease

CM Chen, IC Chen, YC Huang, HF Juan, GJ Lee-Chen, YR Wu

MOVEMENT DISORDERS 28, S407-S407

Studies of Cap Independent Internal Ribosome Entry Segment Activity of ATXN8OS RNA

Hsin-Chieh Shiau, I-Cheng Chen, Hsuan-Yuan Lin, Ming-Tsan Su, Guey-Jen Lee-Chen

Bio Formosa 47, 1-7

ATXN 8− 62 G/A promoter polymorphism and risk of Taiwanese Parkinson’s disease

I‐C Chen, Y‐R Wu, S‐J Yang, S‐H Kao, Y‐C Chen, K‐H Chang, C‐M Lee, G‐J Lee‐Chen, C‐M Chen

European Journal of Neurology 19 (11), 1462-1469

Temporally controlled modulation of FGF/ERK signaling directs midbrain dopaminergic neural progenitor fate in mouse and human pluripotent stem cells

Ines Jaeger, Charles Arber, Jessica R Risner-Janiczek, Judit Kuechler, Diana Pritzsche, I-Cheng Chen, Thulasi Naveenan, Mark A Ungless, Meng Li

Development 138 (20), 4363-4374

ATP13A2 variability in Taiwanese Parkinson’s disease

Chiung‐Mei Chen, Chih‐Hsin Lin, Hsueh‐Fen Juan, Fen‐Ju Hu, Ya‐Chin Hsiao, Hsin‐Yi Chang, Chih‐Ying Chao, I‐Cheng Chen, Li‐Ching Lee, Tsu‐Wei Wang, Ya‐Tang Chen, Yi‐Tsun Chen, Guey‐Jen Lee‐Chen, Yih‐Ru Wu

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156 (6), 720-729

Spinocerebellar ataxia type 8 larger triplet expansion alters histone modification and induces RNA foci

I-Cheng Chen, Hsuan-Yuan Lin, Ghin-Chueh Lee, Shih-Huan Kao, Chiung-Mei Chen, Yih-Ru Wu, Hsiu-Mei Hsieh-Li, Ming-Tsan Su, Guey-Jen Lee-Chen

BMC Molecular Biology 10, 1-10

ATXN8 opposite strand RNA can be translated through a non-classic AUG initiation codon

I-C Chen, H-Y Lin, Y-C Hsiao, C-M Chen, Y-R Wu, Y-F Shen, K-S Huang, G-J Lee-Chen

JOURNAL OF NEUROCHEMISTRY 110, 96-96

SCA8 repeat expansion: large CTA/CTG repeat alleles in neurological disorders and functional implications

Yih-Ru Wu, I-Cheng Chen, Bing-Wen Soong, Shih-Huan Kao, Ghin-Chueh Lee, Shu-Yi Huang, Hon-Chung Fung, Guey-Jen Lee-Chen, Chiung-Mei Chen

Human genetics 125, 437-444

Nuclear receptor NR4A2 IVS6 +18insG and brain derived neurotrophic factor (BDNF) V66M polymorphisms and risk of Taiwanese parkinson’s disease

Chiung‐Mei Chen, I‐Cheng Chen, Kuo‐Hsuan Chang, Yi‐Chun Chen, Rong‐Kuo Lyu, Yen‐Tzu Liu, Fen‐Ju Hu, Chih‐Ying Chao, Guey‐Jen Lee‐Chen, Yih‐Ru Wu

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144 (4), 458-462

α-Synuclein promoter RsaI T-to-C polymorphism and the risk of Parkinson’s disease

CK Wang, CM Chen, CY Chang, KH Chang, IC Chen, ML Li, G-J Lee-Chen, YR Wu

Journal of neural transmission 113, 1425-1433

First report of two Taiwanese siblings with sialidosis type I: a 10-year follow-up study

Chiung-Mei Chen, Szu-Chia Lai, I-Cheng Chen, Kai-Cheng Hsu, Rong-Kuo Lyu, Long-Sun Ro, Hong-Shiu Chang

Journal of the neurological sciences 247 (1), 65-69

Recurrent cerebral venous thrombosis: An Arg359X mutation in the antithrombin gene in a Taiwanese family

Chiung-Mei Chen, Guey-Jen Lee-Chen, Yih-Ru Wu, Cheng-Yueh Lin, Chi-Jen Chen, I-Cheng Chen, Long-Sun Ro

Thrombosis research 118 (2), 235-240

Plausible pathogenesis of SCA8 CTG trinucleotide repeats expansion

IC Chen, HC Shiau, HY Lin, SH Kao, CM Chen, GJ Lee-Chen

International Journal of Developmental Neuroscience 8 (24), 538

Expanded trinucleotide repeats in the TBP/SCA17 gene mapped to chromosome 6q27 are associated with schizophrenia

Chiung-Mei Chen, Hsien-Yuan Lane, Yih-Ru Wu, Long-Sun Ro, Fen-Lin Chen, Wei-Ling Hung, Yi-Ting Hou, Cheng-Yueh Lin, Shu-Yi Huang, I-Cheng Chen, Bing-Wen Soong, Ming-Liang Li, Hsiu-Mei Hsieh-Li, Ming-Tsan Su, Guey-Jen Lee-Chen

Schizophrenia research 78 (2-3), 131-136